Review Question - QID 218072

A 68-year-old otherwise healthy female presents with a 2-month history of worsening left knee pain. She states she had a knee replacement 5 years ago, as shown in Figure A, and it has never felt right. She complains of buckling events that cause her to stumble. On physical examination, she has considerable laxity with varus and valgus stress in both flexion and extension. She also has a small (0.5x0.5cm) wound along her surgical incision proximal to the patella that has been draining for the past 2 weeks. Her ESR is 80 mm/h and her CRP is 4.5 mg/dL. Aspiration reveals methicillin-resistant enterococcus species. Which of the following would be an appropriate treatment for this patient?