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Originates from hematopoietic cells from a macrophage lineage
79%
3429/4363
Derived from undifferentiated mesenchymal cells
11%
466/4363
They are former osteoblasts trapped in the matrix they produced
4%
180/4363
They become cartilage under intermediate strain and low oxygen tension
2%
84/4363
They form bone by producing non-mineralized matrix
172/4363
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The image shown in Figure A shows an osteoclast remodeling cortical bone through a cutting cone mechanism. Osteoclasts orginate from hematopoietic cells from a macrophage cell lineage. Osteoclasts can be distinguished from other bone cells by their multinucleated giant cells and ruffled border on the cell periphery which increases the surface area for bone resorption. Their main function is to reabsorb bone after being stimulated by RANK-L and IL-1. A balance between osteoclast and osteoblast activity is necessary for a stable calcium level in the blood. Caterson et al. review mesenchymal stem cells and their ability to regenerate musculoskeletal tissue. They state that potential applications include replacement of bone graft for segmental defects, nonunions, spinal fusions, and articular resurfacing. Illustration A shows the differences between osteoblasts, osteoclasts and osteocytes. Video V describes the role and function of osteoblasts and osteocytes. Incorrect Answers: Answer 2: This is true of osteoblasts. Answer 3: This is true of osteocytes. Answer 4: This is true of osteoprogenitor cells. Answer 5: This is true of osteoblasts.
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