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Decreased urinary N-telopeptide and increased urinary alpha-C-telopeptide
4%
130/3098
Low serum vitamin D levels
9%
279/3098
Increased urinary N-telopeptide and decreased urinary alpha-C-telopeptide
18%
555/3098
Increased urinary N-telopeptide and alpha-C-telopeptide
60%
1856/3098
Increased urinary N-telopeptide and decreased urinary excretion of pyridinium crosslinks
8%
250/3098
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Figure A and B, show a representative radiograph and biopsy of a patient with Paget's disease. This is a condition characterized by increased bone resorption, bone formation, and remodeling. This results in altered bone quality, thickening, enlargement, and deformity as seen in Figure A. Current treatment is with bisphosphonates to block osteoclast activity. Urinary N-telopeptide, alpha-C-telopeptide, and pyridinium crosslinks are all biochemical markers of bone turnover. Delmas reviews the biochemical markers of bone turnover and its possible treatment implications in Pagets. Delmas found that patients treated with bisphosponates had near normal laboratory findings for bone turnover.
2.8
(36)
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