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Review Question - QID 3198

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QID 3198 (Type "3198" in App Search)
The disease shown in the radiograph and biopsy specimen, Figures A and B, is best characterized by which of the following laboratory findings
  • A
  • B

Decreased urinary N-telopeptide and increased urinary alpha-C-telopeptide

4%

130/3098

Low serum vitamin D levels

9%

279/3098

Increased urinary N-telopeptide and decreased urinary alpha-C-telopeptide

18%

555/3098

Increased urinary N-telopeptide and alpha-C-telopeptide

60%

1856/3098

Increased urinary N-telopeptide and decreased urinary excretion of pyridinium crosslinks

8%

250/3098

  • A
  • B

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Figure A and B, show a representative radiograph and biopsy of a patient with Paget's disease. This is a condition characterized by increased bone resorption, bone formation, and remodeling. This results in altered bone quality, thickening, enlargement, and deformity as seen in Figure A.

Current treatment is with bisphosphonates to block osteoclast activity. Urinary N-telopeptide, alpha-C-telopeptide, and pyridinium crosslinks are all biochemical markers of bone turnover.

Delmas reviews the biochemical markers of bone turnover and its possible treatment implications in Pagets. Delmas found that patients treated with bisphosponates had near normal laboratory findings for bone turnover.

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