4.1 of 24 Ratings
A 30-year-old patient presents with right elbow pain with a palpable nodule over the olecranon of several months duration. Figures A and B demonstrate AP and lateral radiographs of the right elbow. Figure C demonstrates the histology of the lesion. What are the most likely laboratory and genetic abnormalities present?
Hypercalcemia; Isocitrate dehydrogenase 1
Hyperphosphatemia; Fibroblast growth factor 23
Hypovitaminosis D; Alpha-1 hydroxylase
Elevated creatinine kinase; dystrophin
Hyperphosphatasia; Activin A receptor type 1C
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A 59-year-old dialysis-dependent diabetic caucasian female complains of palpable bump over her right hip. She denies pain in the hip and has not noticed any other bumps on any of her extremities. On physical exam, the bump is nontender and does not limit range of motion. A radiograph is provided in Figure A. What is the most likely diagnosis?
Calcinosis of renal failure
A 30-year-old African-American female presents to your clinic with right hip swelling. These symptoms have been present for over 3 years, but this is the first time she is seeking treatment. Figures A-E show radiographs, an MRI, and histology. What is the most likely diagnosis?
Bizarre Parosteal Osteochondromatous Proliferation (Nora's disease)