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A 12-year-old boy was diagnosed with Li–Fraumeni syndrome. The origin of his syndrome is related to a germ-line mutation of the tumor suppressor p53 gene. What is most common primary bone tumor associated with this gene mutation?
Spindle cell sarcoma of bone
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A 24-year-old man "twists" his knee in a softball accident. He denies any preceding complaints and is very active and healthy. Figures A and B include radiographs and histology of the lesion. These findings are most consistent with what diagnosis?
A 47-year-old man presents with increasing left knee pain and swelling. There is no history of trauma and he is otherwise healthy. Representative radiograph, MRI, and histology are shown in Figures A through D. What is the most likely diagnosis?
Giant cell tumor