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Review Question - QID 213906

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QID 213906 (Type "213906" in App Search)
Which of the following cells involved in bone metabolism derives from a myeloid origin?







Osteoprogenitor cell









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The preosteoclast (precursor to the osteoclast) is the only cell of myeloid origin. The remainder of the cells involved in bone formation, remodeling, and metabolism are of mesenchymal origin.

Osteoclast signaling, function, and biology have grown increasingly well understood over the past few decades. Osteoclast activity is regulated by osteoblasts, thereby coupling bone formation and resorption. Osteoclast differentiation from myeloid precursor cells is stimulated by key molecules including RANK, PU-1, and CSF-1. An understanding of these molecular pathways is essential to developing effective directed anti-resorptive therapies.

Zaidi et al. present a comprehensive review of proliferation, differentiation, and hormonal regulation of cells of the bone. The authors specifically discuss the unique origin of the osteoclast from the myeloid lineage and conversely the mesenchymal origin of the osteoblast. Furthermore, they highlight the most recent understanding of the molecular mechanisms involved in osteoclast formation and signaling, including M-CSF and RANKL.

Caterson et al. discusses mesenchymal differentiation in the context of musculoskeletal regeneration. The authors review the growth factors and bioactive signaling molecules involved in directed differentiation itno the various mesodermal lineages including bone, cartilage, muscle, tendon, marrow, and adipose. They emphasize the importance of understanding these pathways to regenerative medicine.

Illustration A is a diagram illustrating the difference between mesenchymal and myeloid lineages.

Incorrect answers:
Answer 1-4: All of these cells are of shared mesenchymal origin.

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