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A 23-year-old male football player presents to your office with complaints of a painful mass in his anterior thigh. The patient reports the mass is tender to the touch and is associated with local swelling. He has also noticed decreased range of motion to the ipsilateral knee since the mass appeared. Representative XR and MRI are shown in Figures A and B. Which of the following is most closely linked to this patient's condition?
Cartilage oligomeric matrix protein gene mutation
Abnormal type X collagen
Reciprocal translocation involving chromosomes 9 and 22
History of thigh trauma
p53 tumor suppressor gene mutation
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Three years after total knee arthroplasty, a 66-year-old male patient with a history of previously treated prostate cancer presents with right knee stiffness and swelling for 6 months after being struck in the anterior thigh by a baseball. Range of active motion is 10 to 40 degrees. Imaging and gross and microscopic appearance of the lesion are seen in Figures A-F. What is the diagnosis?
Ossifying soft tissue metastasis
A 26-year-old man presents with generalized back and joint stiffness and difficulty opening his mouth. His elder sister has similar complaints. Since childhood, he has had 3 surgeries for excision of recurrent bony prominences around his knees. He walks with a stooped over posture seen in Figure A. Radiographs of his feet, knee, hip and spine are seen in Figures B-E respectively. This patient will likely have:
Elevated serum phosphate and serum creatinine
Mutation in ACVR1 gene
HLA B27 antigen
Mutation in EXT gene
A 25-year-old male presents complaining of a groin mass which he noticed after a football injury that occurred 1 year ago. He states he was struck in the groin with an opposing player's helmet during a tackle and had a large amount of bruising and pain. While his pain and bruising subsided, he states he noticed this groin mass soon there after and that it hasn't grown and is non-tender. He is otherwise healthy. Inlet pelvis radiograph and T2 MRI with gadolinium scan are shown in Figures A and B. What is the most likely diagnosis?