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A 26-year-old man presents with generalized back and joint stiffness and difficulty opening his mouth. His elder sister has similar complaints. Since childhood, he has had 3 surgeries for excision of recurrent bony prominences around his knees. He walks with a stooped over posture seen in Figure A. Radiographs of his feet, knee, hip and spine are seen in Figures B-E respectively. This patient will likely have:
Elevated serum phosphate and serum creatinine
Mutation in ACVR1 gene
HLA B27 antigen
Mutation in EXT gene
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Three years after total knee arthroplasty, a 66-year-old male patient with a history of previously treated prostate cancer presents with right knee stiffness and swelling for 6 months after being struck in the anterior thigh by a baseball. Range of active motion is 10 to 40 degrees. Imaging and gross and microscopic appearance of the lesion are seen in Figures A-F. What is the diagnosis?
Ossifying soft tissue metastasis
A 25-year-old male presents complaining of a groin mass which he noticed after a football injury that occurred 1 year ago. He states he was struck in the groin with an opposing player's helmet during a tackle and had a large amount of bruising and pain. While his pain and bruising subsided, he states he noticed this groin mass soon there after and that it hasn't grown and is non-tender. He is otherwise healthy. Inlet pelvis radiograph and T2 MRI with gadolinium scan are shown in Figures A and B. What is the most likely diagnosis?