Work of ARTicular Cartilage Repair Webinar 2026

Join our virtual Work of ART Webinar series with expert surgeons

Join orthopaedic experts for a three-part webinar series exploring real-world decision making and surgical techniques for adult knee cartilage repair. Through case-based presentations, faculty will share practical insights, surgical information and patient considerations drawn from their clinical experience.

This Work of ARTicular Cartilage Repair session will feature MACI (autologous cultured chondrocytes on porcine collagen membrane) with various concomitant procedures through case study presentations highlighting clinical decision making in cartilage repair procedures and treating the knee as an organ. Through real-world cases, faculty will discuss treatment selection, surgical technique and the reasoning behind each step.

Key takeaways will include pearls on fixation choices, what to do with bony involvement, and much more!  Faculty will also share insights on patient counseling, including expectations during rehabilitation and recovery following cartilage repair procedures.

These speakers are compensated by Vericel Corporation.  This series is not intended to provide medical advice.  Individual results will vary. Financial support for this event page placement was provided by Vericel.

INDICATION

MACI® (autologous cultured chondrocytes on porcine collagen membrane) is an autologous cellularized scaffold

product indicated for the repair of single or multiple symptomatic, full-thickness cartilage defects of the knee with or

without bone involvement in adults.

Limitations of Use

• Effectiveness of MACI in joints other than the knee has not been established.

• Safety and effectiveness of MACI in patients over the age of 55 years have not been established.

IMPORTANT SAFETY INFORMATION

Contraindications: MACI is contraindicated in patients with a known history of hypersensitivity to gentamicin,

other aminoglycosides, products of porcine or bovine origin; in patients with severe osteoarthritis of the knee,

inflammatory arthritis, inflammatory joint disease, or uncorrected congenital blood coagulation disorders; in patients

who have undergone prior knee surgery in the past 6 months, excluding surgery to procure a biopsy or a

concomitant procedure to prepare the knee for a MACI implant; or in patients unable to cooperate with a physicianprescribed

post-surgical rehabilitation program.

Warnings and Precautions:

• Malignancy: The risk of MACI in patients with malignancy in the area of cartilage biopsy or implant is

unknown. Expansion of malignant or dysplastic cells present in biopsy tissue during manufacture and

subsequent implantation may be possible.

• Transmissible infectious diseases: Because patients undergoing procedures associated with MACI are not

routinely tested for transmissible infectious diseases, cartilage biopsy and MACI implant may carry risk of

transmitting infectious diseases.

• Presurgical Comorbidities: Local inflammation or active infection in the bone, joint, and surrounding soft

tissue, meniscal pathology, cruciate ligament instability, and misalignment should be assessed and treated

prior to or concurrent with MACI implantation.

• Product Sterility: Final sterility test results are not available at the time of shipping.

Adverse Reactions: The most frequently occurring adverse reactions reported for MACI (≥5%) were arthralgia,

tendonitis, back pain, joint swelling, and joint effusion. Serious adverse reactions reported for MACI were

arthralgia, cartilage injury, meniscus injury, treatment failure, and osteoarthritis.

Specific Populations:

• Use of MACI in pediatric patients (younger than 18 years of age) or in patients over 65 years of age has not

been established.

• The MACI implant is not recommended during pregnancy. For implantations post-pregnancy, the safety of

breastfeeding to an infant has not been determined.

To report negative side effects, contact Vericel Corporation at 1-800-453-6948 or FDA at 1-800-FDA-1088 (1-800-

332-1088) or www.fda.gov/medwatch.

Please see Full Prescribing Information.

MACI®, Vericel®, and the Vericel logo are registered trademarks of Vericel Corporation.

©2026 Vericel Corporation. All rights reserved.