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Articular cartilage progenitor cells (chondrocyte stem cell population) have been identified in the surface zone (superficial tangential zone) of cartilage. Articular cartilage can be divided into different layers, or zones, at various depths that are based on collagen orientation, chondrocyte organization, and proteoglycan distribution. The superficial tangential zone has collagen fibers and disk-shaped chondrocytes paralleling the articular surface and they have a low proteoglycan concentration, high collagen, and high water concentrations. Dowthwaite et al. used fibronectin in an in vitro differential adhesion assay to identify and describe articular cartilage progenitor cells. They were able to isolate articular cartilage progenitor cells from the surface zone of articular cartilage. Illustration A demonstrates the histology of the articular cartilage layers with H&E staining. Incorrect Answers: 2: Middle zone 3: Deep zone 4: Lamina splendens 5: Tidemark
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