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Review Question - QID 114

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QID 114 (Type "114" in App Search)
Which of the following statements regarding articular cartilage is TRUE?

Cartilage is an isotropic material

10%

124/1237

Most of the water in articular cartilage exists in the deep layer next to the calcified cartilage

19%

230/1237

Cartilage only heals if the injury does not pass through the tidemark

17%

209/1237

Calcified cartilage is the only place that type IV collagen is found

5%

66/1237

Cartilage exhibits stress shielding of the solid matrix components

48%

599/1237

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Cartilage exhibits significant stress shielding of the solid matrix components due to its high water content, the non-compressibility of water, and the structural organization of collagen and proteoglycans. Cartilage is composed of a permeable porous matrix and 65 to 80% of the total weight of articular cartilage is made up of water. A pressure gradient causes the water to flow through the porous-permeable solid matrix. Significant flow of fluid through the solid matrix requires high hydrodynamic pressures because of the low permeability of the solid matrix.

The other answers are incorrect because cartilage is anisotropic, most of the water is located in the superficial layers, it only heals if the injury does pass through the tidemark, type X collagen is found in calcified cartilage and is thought to be involved in mineralization. Type IV collagen is found in the basal lamina.

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