The Lisfranc joint is formed by the articulation between the metatarsal bones (M1 to M5) and tarsal bones (cuneiforms C1 to C3 and cuboid). The Lisfranc ligament is a 3-component structure connecting the medial cuneiform (C1) to the 2nd metatarsal (M2). The Lisfranc joint can be disrupted by a sprain, subluxation, joint widening with or without fracture, dislocation, or crush injury (see Image. Lisfranc Dislocation). Lisfranc injuries are uncommon, affecting 1 in every 55,000 people in the United States. However, these conditions are often misdiagnosed and mismanaged, and up to 20% are initially missed. Lisfranc injuries produce disabling complications such as midfoot arthritis, chronic pain, and functional foot instability, especially when not managed properly.