The in vivo fretting behavior of modular hip prostheses was simulated to determine the effects of material combination and a unique TiN/AlN coating on fretting and corrosion at the taper interface. Fretting current, open-circuit potential (OCP), and quantities of soluble debris were measured to determine the role of mechanically assisted crevice corrosion on fretting and corrosion of modular hip tapers. Test groups consisting of similar-alloy (Co-Cr-Mo head/Co-Cr-Mo neck), mixed-alloy (Co-Cr-Mo head/Ti-6Al-4V neck), and TiN/AlN-coated mixed-alloy modular hip taper couples were used. Loads required to initiate fretting were similar for all test groups and were well below loads produced by walking and other physical activities. Decreases in OCP and increases in fretting current observed during long-term cyclic loading were indicative of fretting and corrosion. Current measured after cessation of cyclic loading suggests that once the conditions for crevice corrosion are established, corrosion can continue in the absence of loading. The chemical, mechanical, and electrochemical measurements, along with microscopic inspections of the taper surfaces indicate that the fretting and corrosion behavior of similar- and mixed-alloy taper couples are similar and that the coated samples are more resistant to fretting and corrosion. The results of this study clearly indicate the role of mechanical loading in the corrosion process, and support the hypothesis of mechanically assisted crevice corrosion.