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Notochord
1%
16/1954
Endoderm
19/1954
Limb bud mesoderm
39%
763/1954
Apical ectodermal ridge
58%
1135/1954
Epithelial ectoderm
15/1954
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The apical ectodermal ridge lies directly over the fetal limb bud and directs longitudinal growth of the limb. Illustration A depicts proper limb development following the apical ectodermal ridge. Illustration B demonstrates transverse absence (also known as congenital amputation) following an insult to the apical ectodermal ridge. A vascular injury to the limb bud mesoderm or epithelial ectoderm may result in congenital deformity, but not a complete transverse absence of the limb.
2.7
(36)
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