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Paul D. Kim
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A rare type of chondroma (benign chondrogenic lesion) which occur on
surface of long bones
locationsurface of long bones (under periosteum) in distal femur, proximal humerus, and proximal femur
59% of lesions in
other locations in the hand (metacarpal or phalanges)
secondary to irritation of tendons
well-demarcated, shallow cortical defect
punctate mineralization (calcification) in 1/3.
saucerization of underlying bone
radiographs important to differentiate from chondrosarcoma (histology may be similar)
similar to enchondroma except for increased cellularity
and more malignant looking cells (can look like chondrosarcoma)
bland hyaline cartilage
marginal excision including underlying cortex
severe symptoms interferring with function
lesion will recur if cartilage is left behind
bone graft any large defects
Differentials & Groups
May have similar chondrogenic histology
Treated with marginl excison (2)
Osteochondroma / MHE
Enchondroma / Olliers / Marfuccis
Neurilemoma (soft tissue)
Nodular fasciitis (soft tissue)
Epidermal inclusion cyst
ASSUMPTIONS: (2) assuming no impending fracture
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Qbank (1 Questions)
A 19-year-old male presents with 2 months of night pain in the right shoulder. A radiograph is shown in Figure A and axial CT scan images are found in Figure B and C. A needle biopsy is performed and the representative histology slide is shown in Figure D. What is the most appropriate treatment for this tumor?
Observation with serial radiographs
Irradiation treatment course with maximum dosage of 60 grays
Marginal excision including the underlying cortex
Wide surgical excision
Neoadjuvant chemotherapy, surgical excision, followed by adjuvant chemotherapy
Select Answer to see Preferred Response
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This case is an example of periosteal chondroma which is a rare benign surface lesion composed of cartilage. It can be similar in appearance and location to malignancies such as periosteal osteosarcoma or periosteal chondrosarcoma, so refining a differential diagnosis is important.
Figure A shows an eccentric, longitudinally oriented periosteal mass with an outer, sclerotic shell of reactive periosteum. Pressure from growth of the lesion may create a saucer shaped or complex shaped defect in the underlying bone. Periosteal chondromas can look similar to osteochondromas but they do not have a stalk or peduncle and myositis ossificans rarely involves the cortex like periosteal chondromas do.
Figures B and C show axial CT images illustrating the tumor extension from the underlying cortex.
Figure D shows a medium power histology of a periosteal chondroma displaying chondroid matrix with multiple chondrocytes in lacunae. Treatment of periosteal chondromas includes marginal excision including the underlying cortex.
The level 4 review by Lewis et al. presents a literature review and 10 cases of periosteal chondroma. They reported that all were treated by marginal or intralesional excision and there were no recurrences found.
Periosteal chondroma. A report of ten cases and review of the literature.
Lewis MM, Kenan S, Yabut SM, Norman A, Steiner G.
Clin Orthop Relat Res. 1990 Jul;(256):185-92.
PMID: 2194723 (Link to Pubmed)
Michael Hughes MD
Ben Taylor MD
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