Review Question - QID 638

Giant cell tumor presents as a lytic lesion in the metaphysis and epiphysis of long bones, most frequently affecting the knee (as shown). It is characterized by proliferation of mononuclear stromal cells and the presence of multi-nucleated giant cells with homogenous distribution (figure B). Although benign, it is locally aggressive and deserves treatments that include extended curettage followed by cement or bone grafting. Malignancy is rarely associated with GCT but may be found in a recurrent tumor or years after irradiation of a previously benign GCT. The cited reference by Turcotte et al is a review article discussing the clinical presentation, evaluation, and treatment of giant cell tumors.